Immature osteoblastic MG63 cells possess two calcitonin gene-related peptide receptor subtypes that differentially respond to [Cys(Acm)]-CGRP and CGRP8-37
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چکیده
Address all correspondence to: Tomoyuki Kawase, D.D.S., Ph.D., Division of Cellular Pharmacolgy, Department of Signal Transduction Research, Graduate School of Medical and Dental Sciences, Niigata University 2-5274 Gakkocho-dori, Niigata 951-8514, Japan Phone/Fax +81-25-227-2927 [email protected] Articles in PresS. Am J Physiol Cell Physiol (June 15, 2005). doi:10.1152/ajpcell.00504.2004
منابع مشابه
Immature osteoblastic MG63 cells possess two calcitonin gene-related peptide receptor subtypes that respond differently to [Cys(Acm)] calcitonin gene-related peptide and CGRP8–37
Tomoyuki Kawase, Kazuhiro Okuda, and Douglas M. Burns Division of Cellular Pharmacology, Department of Signal Transduction Research, and Division of Periodontology, Department of Oral Biological Science, Graduate School of Medical and Dental Sciences, Niigata University, Niigata, Japan; and Medical Research Service, Kansas City Department of Veterans Affairs Medical Center, and Department of Bi...
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Calcitonin gene-related peptide (CGRP) is clearly an anabolic factor in skeletal tissue, but the distribution of CGRP receptor (CGRPR) subtypes in osteoblastic cells is poorly understood. We previously demonstrated that the CGRPR expressed in osteoblastic MG63 cells does not match exactly the known characteristics of the classic subtype 1 receptor (CGRPR1). The aim of the present study was to f...
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Calcitonin gene-related peptide (CGRP) is highly potent vasodilator and contains a disulfide bridge between cysteine residues (Cys) at positions 2 and 7, which is required for biological activity. Co-expression of receptor activity-modifying proteins (RAMPs) with calcitonin receptor 2 (CTR2) or calcitonin receptor-like receptor (CRLR) leads to the formation of four functional heterodimeric rece...
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